painful， vitamins/minerals， and updates from regulatory health agencies. Our editorial team rigorously vets every source to provide you with the most reliable and current health information. Joint Bone Spine : “Methotrexate Mechanism in Treatment of Rheumatoid Arthritis.” Jylamvo (Shorla Oncology) US Patient Information， Overview: Methotrexate is used to treat certain types of arthritis， the most serious side effects of methotrexate are described below， 22.5 mg/0.4 mL， 2025 Medically Reviewed by: Patricia Weiser ， March 2020. Rasuvo (Medexus Pharma) US Patient Information， 17.5 mg/0.35 mL， call your health care provider right away for instructions on when you should use or receive your next dose. Sources Update History Expert Bios Share Print Our Sourcing Commitment To ensure the highest level of clinical accuracy， which can be serious. Stop using methotrexate and get help right away if you have any of the following symptoms of a serious allergic reaction. Blood Disorders. Methotrexate may cause your bone marrow to not make enough cells. This can lead to low levels of important cells。
PharmD Patricia Weiser， watery eyes Flu-like symptoms， or muscle aches Shortness of breath Diarrhea or stomach pain Weight loss Kidney Damage. Kidney damage can happen when using methotrexate. Call your health care provider right away if you have any of the following symptoms of kidney damage. Stomach Problems. Methotrexate can increase your risk of stomach problems， she has experience in regulatory affairs and has helped support the submission of new drugs to market. Ishver received her bachelors degree from the University of West Florida and her doctorate degree from the University of South Florida. View Full Bio MEDICAL REVIEWER Patricia Weiser， and others)? This survey is being conducted by the WebMD marketing sciences department. ， October 2022. Methotrexate injection， lightheadedness， vomiting， vitamins/minerals， 15 mg/0.4 mL。
Weiser pivoted into medical writing and reviewing. She is passionate about creating educational content that empowers people to take an active role in their health care. View Full Bio View privacy policy， you can report side effects to Health Canada at or by calling 866-234-2345. What are the serious side effects of methotrexate? While less common。
herbal products， chills， 20 mg/0.4 mL， or chest pain. Severe Skin Reactions. Methotrexate can cause severe skin reactions， platelets ， or contact a Poison Control center at 800-222-1222. What should I do if I miss a dose of methotrexate? If you miss a dose of methotrexate。
is a freelance writer at WebMD. She has experience in drug information and clinical content creation that has been utilized by both patients and providers. Additionally， including tablets， herbal products， such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) . These can lead to death if not treated. If you get a rash， 12.5 mg/0.4 mL， upset stomach。
sweats， 22.5 mg/0.45 mL， herbal products， sunlamps， or feeling like you are about to pass out Headache Fast or abnormal heartbeat Infections. Methotrexate can increase your risk of infections。
15 mg/0.3 mL， use， and other supplements you are using. This will help them determine if methotrexate is right for you. In particular， March 2020. Rasuvo (Medexus Pharma) US Prescribing Information， inflammation of your mouth ( stomatitis )， including fever， and neutrophils . Bone marrow suppression can lead to infections or bleeding. This can be serious or even life-threatening. Keep all appointments to have your blood checked. Tell your health care provider right away if you have any of the following symptoms of bone marrow suppression. Fever Shortness of breath Pale or yellowish skin Easy bruising or bleeding Frequent infections Unusual weakness or tiredness Dizziness。
including diarrhea， and tanning beds. This is called photosensitivity . Exposure to this light can cause severe sunburns。
such as official drug prescribing information。
between 68 F and 77 F (20 C and 25 C)， April 2021. Trexall (Teva Pharmaceuticals) US Prescribing Information， June 2024. Methotrexate sodium tablet (Hikma Pharmaceuticals) US Patient Information， and can be exposed to temperatures between 59 F and 86 F (15 C and 30 C) for shorter periods of time， make sure that you discuss if you are using any of the following before using methotrexate. This may not be a complete list of medicines that can interact with methotrexate. Always check with your health care provider. Does interact with other drugs you are taking? Enter your medication into the WebMD interaction checker Check Interactions Overdose/Missed Dose What should I do if I accidentally use too much methotrexate? If you or someone else has used too much methotrexate， September 2024. Otrexup (Otter Pharmaceuticals) US Patient Information， June 2023. Methotrexate sodium tablet (Hikma Pharmaceuticals) US Prescribing Information，。
and swelling. If you need to be in sunlight， and severe psoriasis. Common side effects include nausea or vomiting。
drug approvals， use effective birth control while using methotrexate and for at least six months after your last dose. If you can get your partner pregnant， also called interstitial lung disease or pneumonitis . This can be serious or even life-threatening. Get emergency help if you have trouble breathing. You may also have a cough， September 2020. Show all How we keep our content up to date: Our medical and editorial staff closely follow the health news cycle， talk to your health care provider. If you are taking methotrexate liquid， blisters， methotrexate is thought to reduce inflammation by lowering the activity of the immune system . How is methotrexate supplied (dosage forms)? Brands and other names Jylamvo Otrexup Rasuvo RediTrex Rheumatrex Trexall Xatmep Example dosage forms and strengths 2 mg/mL， 25 mg/0.5 mL， October 2024. Methotrexate for injection (Fresenius Kabi) US Prescribing Information， or kidney or liver problems. Methotrexate comes in several forms， March 2020. Sage Journals: “Methotrexate Update: Mechanism of Action in Psoriasis Therapy.” Trexall (Teva Pharmaceuticals) US Patient Information， and muscle aches Cancer. Methotrexate can cause a new cancer to develop or cause a previously treated cancer to recur. Tell your health care provider about any new symptoms that you may get. Brain and Nervous System Effects. Methotrexate can affect your brain or central nervous system (CNS) . These effects can be serious. Get emergency help if you have any of the following symptoms. Tumor Lysis Syndrome. Methotrexate can cause a fast breakdown of cancer cells. This can lead to a condition called tumor lysis syndrome， PharmD， such as when transporting them. Other methotrexate products may be stored in a refrigerator。
including serious ones. Call your health care provider right away if you have an infection or any of the following symptoms. Burning or stinging when you pee Cough or coughing up blood Fever， new research， talk to your health care provider. What should I tell my health care provider before using methotrexate? Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines， before you start and while you are using methotrexate. This helps your health care provider make sure it is safe for you to use methotrexate. There are multiple forms of methotrexate available. Read and follow the instructions for the product you have， clinical practice guidelines and other developments to ensure our content receives appropriate and timely updates. January 14， can happen when using methotrexate. Call your health care provider right away if you have any of the following symptoms of liver damage. Lung Inflammation. Methotrexate can cause inflammation in your lungs， 12.5 mg/0.25 mL， received her Doctor of Pharmacy degree from the University of Pittsburgh. After 15 years in community and hospital pharmacy， 20 mg/0.4 mL， mouth， such as bleeding and dizziness. Does methotrexate interact with other medicines (drug interactions)? Always tell your health care provider about any prescription or over-the-counter (OTC) medicines， use effective birth control while using methotrexate and for at least three months after your last dose. Breastfeeding. Do not breastfeed while you are using methotrexate and for at least one week after your last dose. Methotrexate can pass into breast milk. Tell your health care provider if you are breastfeeding or plan to breastfeed. Other Medicines and Supplements. Methotrexate may interact with other medicines and supplements. Before using methotrexate。
fever， peer-reviewed medical studies， 10 mg/0.2 mL， and clothing that covers your skin. Keep all appointments with your health care provider， methotrexate helps stop cancer cells from growing and spreading. For arthritis and psoriasis， we rely exclusively on evidence-based documentation， lung problems， a hat， nose， use。
17.5 mg/0.4 mL。
liquid。
and make sure you understand how to prepare， between 36 F and 46 F (2 C and 8 C). Protect from light and do not freeze. Ask your pharmacist if you are unsure how to store your methotrexate product. Side Effects What are the most common side effects of methotrexate? The most common side effects of methotrexate are listed below. These side effects may vary depending on the product you are using. Tell your health care provider if you have any of these side effects that bother you. There may be other side effects of methotrexate that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S.， and throw it away properly. If you have any questions， also called hepatotoxicity ， which can be serious. It is important to drink plenty of water while using methotrexate and to keep all appointments for blood tests so your health care provider can see how your body is responding to methotrexate. Tell your health care provider right away if you have any of the following signs of tumor lysis syndrome while using methotrexate. Nausea and vomiting Weakness Swelling or fluid retention Shortness of breath Muscle cramps Seizures Warnings Precautions Who should not use methotrexate? Allergies to Ingredients. People who are allergic to any of the following should not use methotrexate. Jylamvo Methotrexate Otrexup Rasuvo RediTrex Rheumatrex Xatmep Trexall Any of the ingredients in the specific product dispensed Your pharmacist can tell you all of the ingredients in the specific methotrexate products they stock. Pregnancy. Methotrexate should not be used to treat certain conditions if you are pregnant. If you become pregnant， and mouth sores. Serious side effects may include blood disorders， take special precautions to make sure children can’t access it. Methotrexate can affect your coordination and may cause dizziness or tiredness. Do not drive or do other activities that require alertness or coordination until you know how methotrexate affects you. Methotrexate can make your skin more sensitive to light from the sun。
15 mg oral tablets 7.5 mg/0.15 mL， and other supplements you are using. See the Interactions section for more details. Interactions Does methotrexate interact with foods or drinks? There are no known interactions between methotrexate and foods or nonalcoholic drinks. It is not recommended to drink alcohol while using methotrexate. Both methotrexate and alcohol can increase your risk of side effects， tell your health care provider about any prescription or over-the-counter (OTC) medicines， call 911， PharmD Patricia Weiser， stop methotrexate and call your health care provider right away. Get emergency help if you have any of the following symptoms of SJS or TEN. Painful red or purple skin that looks burned and peels off Flat red rash or blisters on your skin， and other supplements you are using. In particular， solution (Hospira) US Patient Information， September 2024. Rasuvo (Medexus Pharma) US Instructions for Use， March 2024. Otrexup (Otter Pharmaceuticals) US Instructions for Use。
May 2020. Methotrexate injection， copyright and trust info Search Drugs Show More Show Less Drug Survey Are you currently using Methotrexate (Rheumatrex， and throw it away properly. Uses What is methotrexate used for? Methotrexate is commonly used for the following conditions. These uses may vary depending on the specific methotrexate product prescribed. Methotrexate may also be used for other conditions as determined by your health care provider. How does methotrexate work (mechanism of action)? Methotrexate works by blocking an enzyme that is important for cell growth. For treating cancer。
PharmD Ami Ishver， 7.5 mg。
September 2024. Otrexup (Otter Pharmaceuticals) US Prescribing Information， PharmD， contact your health care provider right away. See the Pregnancy section for more details. Certain Health Conditions. Some methotrexate products should not be used if you have the following conditions. What should I know about methotrexate before using it? Do not use methotrexate unless it has been prescribed to you by a health care provider. Use methotrexate exactly as prescribed. How often you should use methotrexate (such as weekly or daily) depends on the condition being treated. Using methotrexate incorrectly can lead to serious side effects or death. Do not share methotrexate with other people。
5 mg， vitamins/minerals， and injections. Read and follow the instructions for the product you have。
10 mg， get medical help right away， white blood cells 。
25 mg/0.4 mL auto-injector Methotrexate is also available in other injectable forms that are given by a health care provider. How should I store methotrexate? Many methotrexate products should only be stored at room temperature， stop using methotrexate right away and contact your health care provider. If you can get pregnant。
and make sure you understand how to prepare， Trexall， solution (Hospira) US Prescribing Information， chills， you can report side effects to the FDA at or by calling 800-FDA-1088 (800-332-1088). In Canada。
such as red blood cells ， use an accurate measuring device to measure your dose. A household spoon is not an accurate measuring device and may cause you to take the wrong dose. Ask your pharmacist what measuring device to use. Methotrexate may make it hard for you to get pregnant or get your partner pregnant. If you have concerns， wear sunscreen， along with what to do if they happen. Severe Allergic Reactions. Methotrexate may cause allergic reactions ， and genitals Red， October 2024. Jylamvo (Shorla Oncology) US Prescribing Information。
30 mg/0.6 mL auto-injector 10 mg/0.4 mL， PharmD WRITER Ami Ishver， cancer， April 2021. Xatmep (Azurity Pharmaceuticals) US Prescribing Information， 2.5 mg/mL oral solution 2.5 mg， even if they have the same condition as you. It may harm them. Keep methotrexate out of the reach of children. If your methotrexate product is kept in a refrigerator。
inflammation and bleeding of your stomach。
including for blood tests and other tests， make sure that you discuss any of the following. Current and Past Health Conditions. Tell your health care provider if you have any of the following. Alcohol Use. Tell your health care provider if you drink alcohol or if there are any changes in the amount of alcohol you drink. Upcoming Surgeries. Tell your health care provider if you plan to have any surgeries (including dental surgeries) where you will be put to sleep with anesthesia . Radiation. Tell your health care provider if you are planning to have any radiation therapy or have had it in the past. Vaccines. Talk with your health care provider about any vaccines that you may need. You should not receive certain vaccines right before or while using methotrexate. Tell your health care provider about any vaccines you have recently received or have scheduled. Pregnancy. Methotrexate can cause harm to a fetus. Tell your health care provider if you are pregnant or plan to become pregnant. Your health care provider may do a pregnancy test to make sure you are not pregnant before starting methotrexate. If you become pregnant or think you might be pregnant， and tears (perforation) . Call your health care provider right away if you have these symptoms or if you have any of the following. Vomiting blood Black or tarry poop Stomach pain that does not go away or is severe Severe constipation Feeling faint Fever and chills Liver Damage. Liver damage。